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Development and Characterization of Buccal Film of Candesartan

Submitted by webadmin on Tue, 10/18/2016 - 14:52
Pharmaceutical Methods,2016,7,2,75-88.
Published:July 2016
Type:Original Article

Development and Characterization of Buccal Film of Candesartan

Dipak Rajaram Malpure1, Sharada Laxman Deore2*

1Department of Pharmaceutical Sciences, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan INDIA.

2Govt. College of Pharmacy, Amravati-444604 MS INDIA.

Abstract:

Candesartan is potent antihypertensive drug of class angiotensin II receptor antagonist. But it exhibits poor water solubility and extensive first pass metabolism. Present research deals with development of candesartan buccal film. Optimisation of buccal film was done by design expert. Optimised concentration range selected for development of trial batches of candesaratanbuccal films. Mucoadhesivebuccal films of candesartan were prepared by solvent casting technique using chitosan, HPMC, gelatin and EDTA as permeation enhancer. Prepared buccal films evaluated for various pharmaceutical parameters, stability studies, in-vitro and ex-vivo evaluation parameters performed. In-vitroangiotensin II receptor antagonist studies were also performed. Results showed improved bioavaibility of candesartan through buccal films.

Pictorial Abstract