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Formulation, Optimization and Characterization of Solid Dispersion of Glibenclamide

Submitted by webadmin on Tue, 10/18/2016 - 16:26
Pharmaceutical Methods,2015,6,2,72-81.
Published:July 2015
Type:Original Article

Formulation, Optimization and Characterization of Solid Dispersion of Glibenclamide

Navneet Dhillon1, Kanav Midha2*, Manju Nagpal2 and Rakesh Pahwa1

1Institute of Pharmaceutical Science, Kurukshetra University, Kurukshetra, INDIA.

2Department of Pharmaceutical Sciences, Research Scholar, Chitkara College of Pharmacy, Chitkara University, Rajpura, INDIA.

Abstract:

Aim: The aim of the present study was to increase the solubility and dissolution of Glibenclamide. Materials and Methods: Various batches of solid dispersion of Glibenclamide using water soluble carriers such as PEG (PEG 4000 and PEG 1500), were prepared as per the design expert (8.0.5) to optimize the drug release profile using response surface methodology (Face centered central composite design). Results: DSC and FTIR were used to characterize the solid dispersions. No chemical interaction was found between Glibenclamide and polymers. F3 and F13 was found to be optimized batch according to the Face centered central composite design (FCCCD). Conclusion: Drug release was directly proportional to the concentration of polymer used for the formulation of solid dispersion. Thus, Glibenclamide with PEG 4000 and PEG 1500 had faster dissolution rate than Glibenclamide itself.

3D response surface plot showing the relationship between various levels of two factors on % solubility