Effect of Zingiber officinale (Ginger) Extract on Acetaminophen- Induced Hepatotoxicity in Mice
This paper was designed to evaluate hepatprotective effects of Zingiber officinale extract against acetaminophen induced hepatotoxicity in mice. Zingiber Officinale (Ginger) is common part of the diet in many parts of the world, recent research has found ginger to have various pharmacological properties due to a variety of active constituents, including shogoals and gingerols. It is a member of Zingiberaceae family originated in Southeast Asia and has been introduced to many parts of the globe where it proliferates in suitable environment. Ginger has many pharmacological action including anti-inflammatory effect, analgesic activity, cytoprotective effect. Ginger also has glucose lowering effect on alloxan and streptozotocin induced diabetes mellitus. Ginger has hepatoprotective effect against carbon tetrachloride induced hepatotoxicity. The present paper aimed to determine pharmacological effect of Zingiber officinale extract in mice on acetaminophen- induced hepatoxicity in mice. Zingiber officinale extract has hepatoprotective effects due to its antioxidant effect.