Application of UV spectrophotometric method for easy and rapid estimation of sulfasalazine in pharmaceutical formulation (suspension)


Author(s): Yasir Mehmood, Noviara Saleem, Muhammad Ali Syed, and Sana Hanif

Introduction: The present research work is about the development of a simple, economic, accurate, quick and reproducible UV spectrophotometric method for sulfasalazine (SFZ) estimation in the pharmaceutical formulation (suspension) and also when it is in the bulk. Materials and Methods: Water and methanol was used in proportion of 1:1 for the preparation of stock solution. Different solutions of SFZ were prepared by diluting the stock solution with water. Results: The solution was prepared and determine at wavelength λmax 359 nm. The drug was determined at maximum wavelength (λmax 359 nm). When the drug concentration is in the range of 2–20 μg/ml it obeys Beers law with line equation y=0.073x+0.003 and correlation coefficient of 0.992. Results obtained were validated statistically and by recovery study method. Conclusion: The result of analysis was validated according to ICH guidelines and this proposed method can be used for the routine analysis of sulfasalazine suspension formulation.

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