First-order derivative spectrophotometric estimation of nabumetone and paracetamol in tablet dosage form


Author(s): Ambadas R. Rote, and Swapnil R. Bhalerao

Aim: To develop and validate a simple, precise and accurate spectrophotometric method for the simultaneous estimation of nabumetone and paracetamol in their combined tablet dosage form. This method is based on first-order derivative spectroscopy. Materials and Methods: For determination of sampling wavelengths, each of nabumetone and paracetamol were scanned in the wavelength range of 200–400 nm in the spectrum mode and sampling wavelengths were  selected at 261 nm (zero crossing of nabumetone) where paracetamol showed considerable absorbance and at 248.2 nm (zero crossing of paracetamol) where nabumetone showed considerable absorbance. Results: Beer’s law obeyed in the concentration range of 3-18 µg/ml for both the drugs. The correlation coefficients were found to be 0.9992 and 0.9998 for nabumetone and paracetamol, respectively. Mean recoveries were found satisfactory. Conclusion: The proposed method can be successfully applied for simultaneous estimation of nabumetone and paracetomol.